Burkitt Lymphoma and EBV viremia in a well-controlled HIV patient: A case report


  • Sarah Hanson OSU Center for Health Sciences
  • Steven Buck Oklahoma Cancer Specialists And Research Institute
  • Mousumi Som OSU Center for Health Sciences


Burkitt's Lymphoma, AIDS, EBV viremia


Abstract: We report a case of a 34 year old male with AIDS who presented to the hospital with abdominal pain and dyspnea. He received a comprehensive work-up including extensive imaging and biopsies revealing high grade mature B-cell lymphoma with features consistent with Burkitt’s Lymphoma with concomitant Ebstein Barr viremia. This case demonstrates the need for vigilance when assessing patients with HIV or AIDS for lymphoma with vague complaints and no identifiable source of infection.


Delecluse HJ, Raphael M, Magaud JP, et al. Variable morphology of human immunodeficiency virus-associated lymphomas with c-myc rearrangements. The French Study Group of Pathology for Human Immunodeficiency Virus-Associated Tumors, I. Blood 1993; 82:552.

Bower M, Fisher M, Hill T, et al. CD4 count and the risk of systemic non-Hodgkin’s lymphoma in individuals with HIV in the UK. Haematologica. 2009: 6:875–880.

Guech-Ongey M, Simard EP, Anderson WF, et al. AIDS-related Burkitt lymphoma in the United States: what do age and CD4 lymphocyte patterns tell us about etiology and/or biology? Blood 2010; 116:5600.

Carbone, Antonino. "Emerging pathways in the development of AIDS-related lymphomas." The Lancet Oncology 2003; 4.1:22-29.

Besson C, Goubar A, Gabarre J et al. Changes in AIDS-related lymphoma since the era of highly active antiretroviral therapy. Blood 2001; 8:2339-44.

Shiramizu B, McGrath MS. Molecular pathogenesis of AIDS-associated non-Hodgkin's lymphoma. Hematol Oncol Clin North Am 1991; 5:323.

Ometto L, Menin C, Masiero S, et al. Molecular Profile of Epstein-Barr Virus in Human Immunodeficiency Virus Type 1–Related Lymphadenopathies and Lymphomas. Blood 1997; 90:313-322.

D Shibata, LM Weiss, AM Hernandez, et al. Epstein-Barr virus-associated non-Hodgkin's lymphoma in patients infected with the human immunodeficiency virus. Blood 1993; 81:2102-2109.

Bellan C, Lazzi S, Hummel M, et al. Immunoglobulin gene analysis reveals 2 distinct cells of origin for EBV-positive and EBV-negative Burkitt lymphomas. Blood 2005; 106:1031-1036.

Kersten MJ, Van Gorp J, Pals ST, et al. Expression of Epstein-Barr virus latent genes and adhesion molecules in AIDS-related non-Hodgkin's lymphomas: correlation with histology and CD4-cell number. Leuk Lymphoma 1998; 30:515.

Aberg J, Gallant J, Ghanem K, et al. "Primary Care Guidelines for the Management of Persons Infected with HIV: 2013 update by the HIV Medicine Association of the Infectious Diseases Society of America." Clinical Infectious Disease 2013 58:1-34.